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1

Discovery of a Novel Series of Pyrazolo[1,5-a]pyrimidine-Based Phosphodiesterase 2A Inhibitors Structurally Different from N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915), for the Treatment of Cognitive Disorders

Mikami, Satoshi, Kawasaki, Masanori, Ikeda, Shuhei, Negoro, Nobuyuki, Nakamura, Shinji, Nomura, Izumi, Ashizawa, Tomoko, Kokubo, Hironori, Hoffman, Isaac Dylan, Zou, Hua, Oki, Hideyuki, Uchiyama, Nori

Year:

2017

Language:

english

File:

PDF, 2.14 MB

english, 2017

2

Discovery of Clinical Candidate N -((1 S )-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3- b ]pyrazine-4(1 H )-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders

Mikami, Satoshi, Nakamura, Shinji, Ashizawa, Tomoko, Nomura, Izumi, Kawasaki, Masanori, Sasaki, Shigekazu, Oki, Hideyuki, Kokubo, Hironori, Hoffman, Isaac D., Zou, Hua, Uchiyama, Noriko, Nakashima, Ko

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 2.10 MB

english, 2017

3

Relation Between Vertical Orientation and Stability of Acetabular Component in the Dysplastic Hip Simulated by Nonlinear Three-dimensional Finite Element Method

Hisashi Oki, Masao Ando, Hironori Omori, Yasuhiro Okumura, Kohei Negoro, Kenzo Uchida, Hisatoshi Baba

Journal:

Artificial Organs

Year:

2004

Language:

english

File:

PDF, 217 KB

english, 2004

4

Design and synthesis of potent and selective pyridazin-4(1H)-one-based PDE10A inhibitors interacting with Tyr683 in the PDE10A selectivity pocket

Yoshikawa, Masato, Hitaka, Takenori, Hasui, Tomoaki, Fushimi, Makoto, Kunitomo, Jun, Kokubo, Hironori, Oki, Hideyuki, Nakashima, Kosuke, Taniguchi, Takahiko

Journal:

Bioorganic & Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 810 KB

english, 2016

5

Urodynamics and bladder muscarinic receptors in rats with cerebral infarction and bladder outlet obstruction

Shuji Maruyama, Souhei Kurosawa, Yukiko Takagi, Tomomi Oki, Yukiko Noguchi, Masashi Ukai, Hironori Yuyama, Akiyoshi Ohtake, Masanori Suzuki, Masao Sasamata, Shizuo Yamada

Journal:

Neuroscience Letters

Year:

2007

Language:

english

File:

PDF, 131 KB

english, 2007

6

Successful Treatment of Seasonal Influenza A (H3N2) infection-related Hemophagocytic Lymphocytosis in an Elderly Man

SUZUKI, Shintaro, TANAKA, Akihiko, FUKUDA, Yosuke, MIYATA, Yoshito, MURATA, Yasunori, KISHINO-OKI, Yasunari, HOMMA, Tetsuya, OHNISHI, Tsukasa, SAGARA, Hironori

Journal:

Kansenshogaku zasshi

Year:

2016

File:

PDF, 626 KB

2016

7

Leukemogenesis induced by c-terminal mutations in the basic leucine zipper domain of C/EBPα

Togami, Katsuhiro, Kitaura, Jiro, Inoue, Daichi, Kagiyama, Yuki, Uchida, Tomoyuki, Nishimura, Kotaro, Doki, Noriko, Kato, Naoko, Nakahara, Fumio, Oki, Toshihiko, Harada, Yuka, Harada, Hironori, Kitamu

Journal:

Experimental Hematology

Year:

2013

Language:

english

File:

PDF, 49 KB

english, 2013

8

Delayed Treatment with Arundic Acid Reduces the MPTP-induced Neurotoxicity in Mice

Chie Oki, Yu Watanabe, Hironori Yokoyama, Taiji Shimoda, Hiroyuki Kato, Tsutomu Araki

Journal:

Cellular and Molecular Neurobiology

Year:

2008

Language:

english

File:

PDF, 541 KB

english, 2008

9

Optimization of welding condition for non-linear friction stir welding

TAKAHARA, Hironori, TSUJIKAWA, Masato, CHUNG, Sung Wook, OKAWA, Yuzo, HIGASHI, Kenji, OKI, Sachio

Journal:

Journal of Japan Institute of Light Metals

Year:

2007

File:

PDF, 2.25 MB

2007

10

A phase I/II study of S-1 and irinotecan (IRIS) combined with cetuximab in patients with RAS wild-type metastatic colorectal cancer (KSCC1401)

Samura, Hironori, Oki, Eiji, Okumura, Hiroshi, Yoshida, Takefumi, Kai, Seiichiro, Kobayashi, Kazuma, Kinjo, Tatsuya, Mori, Shinichiro, Tohyama, Tetsuo, Ohgaki, Kippei, Kawanaka, Hirofumi, Makiyama, Ak

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2020

File:

PDF, 884 KB

2020

11

Discovery of 1-[2-Fluoro-4-(1 H -pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1 H -pyrazol-5-yl)pyridazin-4(1 H )-one (TAK-063), a Highly Potent, Selective, and Orally Active Phosphodiesterase 10A (PDE10A) Inhibitor

Kunitomo, Jun, Yoshikawa, Masato, Fushimi, Makoto, Kawada, Akira, Quinn, John F., Oki, Hideyuki, Kokubo, Hironori, Kondo, Mitsuyo, Nakashima, Kosuke, Kamiguchi, Naomi, Suzuki, Kazunori, Kimura, Haruhi

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 3.92 MB

english, 2014

12

Serial Measurement of Polyethylene Wear of Well-Fixed Cementless Metal-Backed Acetabular Component in Total Hip Arthroplasty: An Over 10 Year Follow-up Study

Xuesong Dai, Hironori Omori, Yasuhiro Okumura, Masao Ando, Hisashi Oki, Naoki Hashimoto, Hisatoshi Baba

Journal:

Artificial Organs

Year:

2000

Language:

english

File:

PDF, 1.08 MB

english, 2000

13

A multicenter phase II clinical study of oxaliplatin, folinic acid, and 5-fluorouracil combination chemotherapy as second-line treatment for advanced colorectal cancer: A Japanese experience

Yutaka Ogata, Shoji Tokunaga, Yasunori Emi, Eiji Oki, Hiroshi Saeki, Ken Shirabe, Hirofumi Hasegawa, Noriaki Sadanaga, Hironori Samura, Fumihiko Fujita, Takaho Tanaka, Masaki Kitazono, Manabu Yamamoto

Journal:

Year:

2011

Language:

english

File:

PDF, 188 KB

english, 2011

14

Use of an instrument sandwiched between the hoof and shoe to measure vertical ground reaction forces and three-dimensional acceleration at the walk, trot, and canter in horses

Kai, Makoto, Aoki, Osamu, Hiraga, Atsushi, Oki, Hironori, Tokuriki, Mikihiko

Journal:

American Journal of Veterinary Research

Year:

2000

Language:

english

File:

PDF, 502 KB

english, 2000

15

Benign convulsions with mild gastroenteritis: a report of 10 recent cases detailing clinical varieties

Hironori Komori, Masaomi Wada, Minako Eto, Hiromi Oki, Katsumaro Aida, Tamotsu Fujimoto

Journal:

Brain and Development

Year:

1995

Language:

english

File:

PDF, 721 KB

english, 1995

16

Gene Dropping Analysis of Ancestral Contributions and Allele Survival in Japanese Thoroughbred Population

YAMASHITA, Jun, OKI, Hironori, HASEGAWA, Telhisa, HONDA, Takeshi, NOMURA, Tetsuro

Journal:

Journal of Equine Science

Year:

2010

Language:

english

File:

PDF, 206 KB

english, 2010

17

Analysis of the Sexual Differences of Racing Performance of the Thoroughbred by the Analysis of Covariance

Journal:

Journal of Veterinary Epidemiology

Year:

1986

Language:

english

File:

PDF, 493 KB

english, 1986

18

Possible involvement of RasGRP4 in leukemogenesis

Naoko Watanabe-Okochi, Toshihiko Oki, Yukiko Komeno, Naoko Kato, Koichiro Yuji, Ryoichi Ono, Yuka Harada, Hironori Harada, Yasuhide Hayashi, Hideaki Nakajima, Tetsuya Nosaka, Jiro Kitaura, Toshio Kita

Journal:

International Journal of Hematology

Year:

2009

Language:

english

File:

PDF, 669 KB

english, 2009

19

Optimum Processing and Tool Controls for Three-Dimensional Friction Stir Welding

Takahara, Hironori, Tsujikawa, Masato, Chung, Sung-Wook, Okawa, Yuzo, Oki, Sachio, Higashi, Kenji

Journal:

MATERIALS TRANSACTIONS

Year:

2008

Language:

english

File:

PDF, 232 KB

english, 2008

20

Evaluation of Microvessels in Colorectal Tumors by Narrow Band Imaging Magnification: Including Comparison with Magnifying Chromoendoscopy

Yutaka Okamoto, Hidetaka Watanabe, Keiichi Tominaga, Ryo Oki, Michiko Yamagata, Fumie Yokotsuka, Motoo Ishida, Hironori Masuyama, Hideyuki Hiraishi

Journal:

Digestive Diseases and Sciences

Year:

2011

Language:

english

File:

PDF, 1.37 MB

english, 2011

21

Optimization of Welding Condition for Nonlinear Friction Stir Welding

Takahara, Hironori, Tsujikawa, Masato, Chung, Sung Wook, Okawa, Yuzo, Higashi, Kenji, Oki, Sachio

Journal:

MATERIALS TRANSACTIONS

Year:

2008

Language:

english

File:

PDF, 308 KB

english, 2008

22

Co-localization of NFIA and PPARγ controls the brown fat gene program

Waki, Hironori, Hiraike, Yuta, Yu, Jing, Nakamura, Masahiro, Miyake, Kana, Nagano, Gaku, Suzuki, Ken, Nakaki, Ryo, Kobayashi, Hirofumi, Sun, Wei, Aoyama, Tomohisa, Hirota, Yusuke, Ohno, Haruya, Oki, K

Journal:

Diabetes Research and Clinical Practice

Year:

2016

Language:

english

File:

PDF, 39 KB

english, 2016

23

Estimation of Genetic Trend in Racing Time of Thoroughbred Horse in Japan

OKI, Hironori, SASAKI, Yoshiyuki

Journal:

Nihon Chikusan Gakkaiho

Year:

1996

Language:

english

File:

PDF, 316 KB

english, 1996

24

Construction of a scoring system for predicting the risk of severe gastrointestinal involvement in Henoch-Schönlein Purpura

Nagamori, Tsunehisa, Oka, Hideharu, Koyano, Shin, Takahashi, Hironori, Oki, Junichi, Sato, Yuko, Murono, Koichi, Iseki, Kenichi, Takeguchi, Ryou, Takeda, Takahiro, Sato, Masayuki, Sugai, Rika, Kitamur

Journal:

Year:

2014

Language:

english

File:

PDF, 400 KB

english, 2014

25

Estimation Models for the Morbidity of the Horses Infected with Equine Influenza Virus

SUGITA, Shigeo, OKI, Hironori, HASEGAWA, Telhisa, ISHIDA, Nobushige

Journal:

Journal of Equine Science

Year:

2008

Language:

english

File:

PDF, 84 KB

english, 2008

26

Demographic Analysis of Breeding Structure in Japanese Thoroughbred Population

YAMASHITA, Jun, OKI, Hironori, HASEGAWA, Telhisa, HONDA, Takeshi, NOMURA, Tetsuro

Journal:

Journal of Equine Science

Year:

2010

Language:

english

File:

PDF, 203 KB

english, 2010

27

Design and synthesis of a novel 2-oxindole scaffold as a highly potent and brain-penetrant phosphodiesterase 10A inhibitor

Yoshikawa, Masato, Kamisaki, Haruhi, Kunitomo, Jun, Oki, Hideyuki, Kokubo, Hironori, Suzuki, Akihiro, Ikemoto, Tomomi, Nakashima, Kosuke, Kamiguchi, Naomi, Harada, Akina, Kimura, Haruhide, Taniguchi,

Journal:

Bioorganic & Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.73 MB

english, 2015

28

Phase II trial of an alternating regimen consisting of first-line mFOLFOX6 plus bevacizumab and FOLFIRI plus bevacizumab for patients with metastatic colorectal cancer: FIREFOX plus bevacizumab trial (KSCC0801)

Miwa, Keisuke, Oki, Eiji, Emi, Yasunori, Saeki, Hiroshi, Kusumoto, Tetsuya, Akagi, Yoshito, Ogata, Yutaka, Samura, Hironori, Tokunaga, Shoji, Ishikawa, Hiroshi, Tanaka, Takaho, Sueyoshi, Susumu, Higas

Journal:

International Journal of Clinical Oncology

Year:

2016

Language:

english

File:

PDF, 464 KB

english, 2016

29

Patellar dislocation in achondroplasia

Takamine, Yuji, Kitoh, Hiroshi, Ito, Hironori, Yazaki, Susumu, Oki, Takashi

Journal:

Journal of Pediatric Orthopaedics B

Year:

2008

Language:

english

File:

PDF, 80 KB

english, 2008

30

Estimation of Heritability of Laryngeal Hemiplegia in the Thoroughbred Horse by Gibbs Sampling

IBI, Takayuki, MIYAKE, Takeshi, HOBO, Seiji, OKI, Hironori, ISHIDA, Nobushige, SASAKI, Yoshiyuki

Journal:

Journal of Equine Science

Year:

2003

Language:

english

File:

PDF, 192 KB

english, 2003

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